Maspin mRNA Expression in Breast Cancer
Author Information
Author(s): Bièche I, Girault I, Sabourin J-C, Tozlu S, Driouch K, Vidaud M, Lidereau R
Primary Institution: Centre René Huguenin, France
Hypothesis
The study investigates the prognostic value of maspin mRNA expression in ERα-positive postmenopausal breast carcinomas.
Conclusion
Maspin mRNA overexpression is associated with poor long-term outcomes in ERα-positive postmenopausal breast cancer patients.
Supporting Evidence
- 54.3% of tumors showed altered maspin mRNA expression.
- 31.4% of tumors showed maspin mRNA underexpression.
- 22.9% of tumors showed maspin mRNA overexpression.
- Patients with maspin-overexpressing tumors had a 5-year relapse-free survival of 41.8%.
Takeaway
This study looks at a gene called maspin in breast cancer and finds that when this gene is too active, it can mean worse outcomes for patients.
Methodology
Real-time quantitative RT–PCR was used to quantify maspin mRNA in tissue samples from breast cancer patients.
Limitations
The study is limited to a specific cohort of ERα-positive postmenopausal patients and may not generalize to other populations.
Participant Demographics
105 ERα-positive postmenopausal breast cancer patients, mean age 70.8 years.
Statistical Information
P-Value
0.0011
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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