DNA Methylation of SOX9 and Bladder Cancer Progression
Author Information
Author(s): Aleman A, Adrien L, Lopez-Serra L, Cordon-Cardo C, Esteller M, Belbin T J, Sanchez-Carbayo M
Primary Institution: Spanish National Cancer Center, Madrid, Spain
Hypothesis
Is DNA hypermethylation of SOX9 associated with bladder cancer progression?
Conclusion
SOX9 hypermethylation is frequently observed in bladder cancer and is associated with tumor grade and overall survival.
Supporting Evidence
- SOX9 hypermethylation was found in 56.4% of primary bladder tumors.
- Hypermethylation of SOX9 was significantly associated with tumor grade.
- Patients with SOX9 hypermethylation had shorter overall survival.
Takeaway
This study found that a gene called SOX9 is often turned off in bladder cancer due to a process called hypermethylation, which can help doctors understand how serious the cancer is.
Methodology
The study used CpG microarrays to analyze DNA from bladder tumors and normal tissue, identifying hypermethylated genes associated with cancer progression.
Participant Demographics
The study included 101 bladder cancer patients with varying tumor stages.
Statistical Information
P-Value
p=0.032 for tumor grade; p=0.025 for overall survival
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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