Cimetidine's Effects on Salivary Gland Tumors
Author Information
Author(s): Fukuda Masakatsu, Kusama Kaoru, Sakashita Hideaki
Primary Institution: Meikai University School of Dentistry
Hypothesis
Cimetidine inhibits salivary gland tumor cell adhesion to neural cells and induces apoptosis by blocking NCAM expression.
Conclusion
Cimetidine can block the growth and invasion of salivary gland tumors by inducing apoptosis and down-regulating NCAM expression.
Supporting Evidence
- Cimetidine blocked the adhesion of HSG cells to neural cells.
- Cimetidine induced significant apoptosis in the tumor mass in a nude mouse model.
- Cimetidine down-regulated NCAM expression, which is linked to tumor growth and invasion.
Takeaway
Cimetidine helps stop tumor cells from sticking to nerves and makes them die, which could help treat certain types of cancer.
Methodology
The study used in vitro assays and an in vivo nude mouse model to examine the effects of cimetidine on tumor cell adhesion and apoptosis.
Limitations
The study was conducted in a mouse model, which may not fully replicate human responses.
Participant Demographics
Specific pathogen-free athymic BALB/c female mice, 3–4 weeks of age.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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