Connexin 43 and Pannexin 1 hemichannels as endogenous regulators of innate immunity in sepsis
2024
How Connexin 43 and Pannexin 1 Affect the Immune Response in Sepsis
publication
Evidence: moderate
Author Information
Author(s): Li Jianhua, Lou Li, Chen Weiqiang, Qiang Xiaoling, Zhu Cassie, Wang Haichao
Primary Institution: The Feinstein Institutes for Medical Research, Northwell Health
Hypothesis
Hemichannel molecules like Connexin 43 and Pannexin 1 play critical roles as endogenous regulators of innate immunity in sepsis.
Conclusion
Connexin 43 and Pannexin 1 hemichannels are important for regulating the immune response during sepsis by mediating ATP release and other inflammatory signals.
Supporting Evidence
- Previous studies have shown that high mobility group box 1 (HMGB1) is released by macrophages and plays a role in sepsis.
- Inflammatory stimuli can induce the expression of Connexin 43 and Pannexin 1 in macrophages.
- Blocking hemichannels can reduce inflammation and improve survival in sepsis models.
Takeaway
This study shows that two proteins, Connexin 43 and Pannexin 1, help our body's immune system respond to infections like sepsis by controlling the release of important signals.
Digital Object Identifier (DOI)
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