The Role of SERPINE2 in Human Placenta and Trophoblast Activity
Author Information
Author(s): Chern Schu-Rern, Li Sheng-Hsiang, Chiu Chien-Ling, Chang Hsiao-Ho, Chen Chih-Ping, Tsuen Chen Edmund I
Primary Institution: Mackay Memorial Hospital, Taipei, Taiwan
Hypothesis
What is the expression pattern of SERPINE2 in the human placenta and its role in trophoblast activity?
Conclusion
SERPINE2 is highly expressed in the human placenta during pregnancy and is essential for trophoblast migration, invasion, and tube formation.
Supporting Evidence
- SERPINE2 mRNA levels were about 2.7-fold higher in the third trimester compared to the first trimester.
- Immunohistochemical staining showed SERPINE2 protein in syncytiotrophoblasts and extravillous trophoblasts.
- Knockdown of SERPINE2 significantly reduced trophoblast migration and invasion.
Takeaway
SERPINE2 helps the cells in the placenta move and grow properly during pregnancy.
Methodology
Real-time RT-PCR and immunohistochemical staining were used to analyze SERPINE2 expression in placental tissues from different trimesters.
Participant Demographics
Human placental tissues from first, second, and third trimesters of pregnancy.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website