Decrease of breast cancer cell invasiveness by sodium phenylacetate (NaPa) is associated with an increased expression of adhesive molecules
2001
Sodium Phenylacetate Reduces Breast Cancer Cell Invasiveness
publication
Evidence: moderate
Author Information
Author(s): Vasse M, Thibout D, Paysant J, Legrand E, Soria C, Crépin M
Primary Institution: Laboratoire DIFEMA, Groupe de Recherche MERCI, Faculté de Médecine et Pharmacie de Rouen
Hypothesis
Does sodium phenylacetate (NaPa) affect the invasiveness of breast cancer cells?
Conclusion
Sodium phenylacetate significantly inhibits the invasiveness of breast cancer cells by increasing the expression of certain adhesion molecules.
Supporting Evidence
- NaPa treatment led to an 86% inhibition of MDA-MB-231 cell invasiveness.
- NaPa increased the expression of u-PAR and secretion of MMP-9 in MDA-MB-231 cells.
- Only neutralizing antibodies against LFA-1 reversed the decreased invasiveness of NaPa-treated cells.
Takeaway
Sodium phenylacetate helps stop breast cancer cells from spreading by making them stick better to their surroundings.
Methodology
The study analyzed the effect of NaPa on the invasiveness of breast cancer cell lines using Matrigel.
Digital Object Identifier (DOI)
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