Quality Control of Concentrated Gegen Tang Granules
Author Information
Author(s): Song Jingzheng, Han Quanbin, Qiao Chunfeng, Yip Yuekeung, Xu Hongxi
Primary Institution: Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine
Hypothesis
There was no reliable analytical method available for the quality assessment of GT granules.
Conclusion
A new method using high performance liquid chromatography (HPLC) has been developed for simple and reliable quality control of commercial concentrated GT granules.
Supporting Evidence
- The regression equations revealed good linear relationships (correlation coefficients: 0.9994–0.9998) between the peak areas and concentrations.
- The recovery was between 98.8% and 101.7% with good precision and accuracy.
- Samples from four manufacturers showed similar profiles but contents of the detected markers varied significantly among manufacturers and batches.
Takeaway
Researchers created a new way to check if concentrated herbal medicine called Gegen Tang is good quality, and found that different brands have different amounts of important ingredients.
Methodology
An HPLC method was developed and validated to evaluate the quality of GT granules by analyzing seven marker compounds.
Potential Biases
Potential bias may arise from the selection of manufacturers and batches for analysis.
Limitations
The study did not assess the long-term stability of the method or the effects of different storage conditions on the quality of GT granules.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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