MYH11 Mutations in Breast and Prostate Cancer
Author Information
Author(s): Pia Alhopuro, Auli Karhu, Robert Winqvist, Kati Waltering, Tapio Visakorpi, Lauri Aaltonen
Primary Institution: University of Helsinki
Hypothesis
What is the role of somatic MYH11 mutations in breast and prostate cancers?
Conclusion
Little evidence for a role of somatic MYH11 mutations in the formation of breast or prostate cancers was obtained in this study.
Supporting Evidence
- No somatic MYH11 mutations were found in breast cancer samples.
- One prostate cancer sample had a frameshift mutation c.5798delC.
- The study suggests that somatic MYH11 mutations are not frequent in breast and prostate cancer.
Takeaway
The study looked for changes in a gene called MYH11 in breast and prostate cancer but found very few signs that it plays a role in these cancers.
Methodology
Analyzed 155 breast cancer and 71 prostate cancer samples for mutations in MYH11.
Limitations
Somatic mutations may have been missed due to normal tissue contamination and the study focused only on certain exons.
Participant Demographics
Breast cancer samples from patients diagnosed between 1988 and 1994; prostate cancer samples included various types from untreated and treated patients.
Digital Object Identifier (DOI)
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