NFKB1 Gene Polymorphism and Acute Respiratory Distress Syndrome
Author Information
Author(s): Bajwa Ednan K., Cremer Paul C., Gong Michelle N., Zhai Rihong, Su Li, Thompson B. Taylor, Christiani David C.
Primary Institution: Massachusetts General Hospital, Harvard Medical School
Hypothesis
A known functional polymorphism in the promoter of the NFKB1 gene may affect susceptibility to and outcome from ARDS.
Conclusion
The del/del genotype is associated with an age-dependent increase in odds of developing ARDS and increased mortality.
Supporting Evidence
- Patients with the del/del genotype had increased odds of developing ARDS when younger.
- Del/del patients had higher 60-day mortality compared to other genotypes.
- The study included a large sample size of 1152 patients.
Takeaway
Some people have a gene that makes them more likely to get really sick from a lung problem called ARDS, especially if they are younger.
Methodology
A case control study was conducted among patients admitted to the ICU with risk factors for ARDS, comparing 379 ARDS patients to 793 at-risk controls.
Potential Biases
Ancestry was self-reported, which may introduce false-positive results due to population stratification.
Limitations
Results may not be generalizable to non-Caucasian populations or immunocompromised patients, and NF-κB activity was not measured.
Participant Demographics
The study included Caucasian patients admitted to the ICU with risk factors for ARDS.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI 1.35–20.0
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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