Comparative Genomic Analysis of Streptomyces coelicolor and Streptomyces lividans
Author Information
Author(s): Jayapal Karthik P, Lian Wei, Glod Frank, Sherman David H, Hu Wei-Shou
Primary Institution: University of Minnesota
Hypothesis
What are the genetic differences between Streptomyces coelicolor and Streptomyces lividans that contribute to their phenotypic variations?
Conclusion
The absence of certain genes in S. lividans could explain its ease of DNA transformations and lack of actinorhodin synthesis.
Supporting Evidence
- Five large genomic islands and 18 smaller islets were identified in S. coelicolor that are absent in S. lividans.
- Certain genes in S. coelicolor are active during growth and differentiation, which are missing in S. lividans.
- Absence of the bldB gene in S. lividans is linked to its lack of antibiotic synthesis.
Takeaway
Scientists compared the DNA of two bacteria, S. coelicolor and S. lividans, to see why they behave differently. They found that S. lividans is missing some important genes that S. coelicolor has.
Methodology
Whole genome microarrays were used to compare the genomes of S. coelicolor and S. lividans.
Limitations
The study may not cover all genomic islands present in S. lividans and absent in S. coelicolor.
Digital Object Identifier (DOI)
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