The Role of von Willebrand Factor and Oxidative Stress in Acute Coronary Syndromes
Author Information
Author(s): Zoran Koprivica, Djordjevic Dusica, Vuletic Milena, Zivkovic Vladimir, Barudzic Nevena, Andjelkovic Nebojsa, Djuric Dragan, Iric-Cupic Violeta, Krkeljic Jelena, Vladimir Jakovljevic
Primary Institution: University Hospital Center 'Kragujevac'
Hypothesis
This study aims to investigate the relationship between von Willebrand factor, oxidative stress parameters, and different types of acute coronary syndromes.
Conclusion
The study suggests that patients with acute coronary syndromes have elevated levels of von Willebrand factor and oxidative stress, indicating a need for antioxidant supplementation.
Supporting Evidence
- ACS patients had significantly higher levels of von Willebrand factor activity and antigen compared to healthy controls.
- Patients with ACS showed lower levels of nitric oxide and antioxidant enzyme activities.
- Multivariant logistic regression identified von Willebrand factor antigen and TBARS as significant parameters affected by ACS type.
Takeaway
This study found that people with heart problems have higher levels of a certain protein and lower levels of good stuff that helps protect their hearts, so they might need extra help to stay healthy.
Methodology
The study compared levels of von Willebrand factor activity, antigen, and oxidative stress parameters in 115 patients with acute coronary syndromes to 40 healthy controls.
Limitations
The study was not prospective and had a small number of deceased patients for comparison.
Participant Demographics
{"total_patients":115,"controls":40,"sex_ratio":{"male":74,"female":41},"age":{"patients":"67.0 ± 8.0","controls":"65.0 ± 3.0"}}
Statistical Information
P-Value
0.000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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