Ultrasonographic Features of Combined Hepatocellular-Cholangiocarcinoma and Microvascular Invasion
Author Information
Author(s): Tian HaiYing, Chen Yuling, Zhao LiNa, Liao ChunYan, Li Sha, Zhang Bei
Primary Institution: Guizhou Medical University
Hypothesis
This study aims to investigate the clinicopathological and ultrasonography characteristics of combined hepatocellular-cholangiocarcinoma (cHCC-CCA) and its correlation with microvascular invasion (MVI).
Conclusion
Ultrasonographic and CEUS features have a certain correlation with MVI in cHCC-CCA patients, with specific features serving as independent risk factors.
Supporting Evidence
- MVI-positive tumors had a higher proportion of tumors with a maximum diameter greater than 5 cm.
- Low echo halo, peripheral irregular rim-like enhancement, and early washout were identified as independent risk factors for MVI.
- The area under the curve (AUC) for the predictive factors was 0.8056.
Takeaway
Doctors can use special ultrasound pictures to help figure out if a liver tumor is more likely to spread, which can help them decide how to treat it.
Methodology
A retrospective analysis was conducted on 57 patients diagnosed with cHCC-CCA, comparing clinical data, ultrasonographic findings, and CEUS features between MVI-positive and MVI-negative groups.
Potential Biases
Subjective bias exists when determining tumor morphology and washout characteristics.
Limitations
The study was a single-center retrospective study with possible selection bias and subjective bias in tumor morphology assessment.
Participant Demographics
Patients included 57 individuals diagnosed with cHCC-CCA, with 47.4% MVI-positive and 52.6% MVI-negative.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 1.009, 91.386 for low echo halo; 95% CI: 1.269, 55.056 for peripheral irregular rim-like enhancement; 95% CI: 1.590, 63.412 for early washout.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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