Paternal Contributions to Recurrent Pregnancy Loss
Author Information
Author(s): Kaltsas Aris, Zikopoulos Athanasios, Kojovic Vladimir, Dimitriadis Fotios, Sofikitis Nikolaos, Chrisofos Michael, Zachariou Athanasios
Primary Institution: Attikon University Hospital, School of Medicine, National and Kapodistrian University of Athens
Hypothesis
This review aims to comprehensively examine male contributions to pregnancy loss, focusing on underlying mechanisms, novel biomarkers, and integrated strategies for improved reproductive success.
Conclusion
Integrating paternal factors into clinical evaluations is crucial for effectively addressing recurrent pregnancy loss.
Supporting Evidence
- Paternal factors such as advanced age and health issues significantly affect sperm integrity.
- Advanced paternal age is associated with increased risks of miscarriage and adverse pregnancy outcomes.
- Novel sperm proteomic biomarkers have been identified, offering potential for enhanced diagnostics.
- Integrated approaches involving multidisciplinary assessments are essential for effectively addressing RPL.
Takeaway
Dads can affect pregnancy outcomes too! Their health and lifestyle choices can impact the chances of having a baby.
Methodology
A comprehensive narrative review was conducted by searching databases including PubMed and Embase for literature published from January 2004 to October 2024.
Potential Biases
Limited attention to paternal factors in clinical assessments may lead to biased evaluations of pregnancy loss.
Limitations
The underrepresentation of paternal factors in clinical practices and variability in diagnostic protocols across institutions.
Digital Object Identifier (DOI)
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