Minimally Invasive Approach for Acute Necrotizing Pancreatitis
Author Information
Author(s): Besselink Marc GH, van Santvoort Hjalmar C, Nieuwenhuijs Vincent B, Boermeester Marja A, Bollen Thomas L, Buskens Erik, Dejong Cornelis HC, van Eijck Casper HJ, van Goor Harry, Hofker Sijbrand S, Lameris Johan S, van Leeuwen Maarten S, Ploeg Rutger J, van Ramshorst Bert, Schaapherder Alexander FM, Cuesta Miguel A, Consten Esther CJ, Gouma Dirk J, van der Harst Erwin, Hesselink Eric J, Houdijk Lex PJ, Karsten Tom M, van Laarhoven Cees JHM, Pierie Jean-Pierre EN, Rosman Camiel, Bilgen Ernst Jan Spillenaar, Timmer Robin, van der Tweel Ingeborg, de Wit Ralph J, Witteman Ben JM, Gooszen Hein G
Primary Institution: University Medical Center Utrecht
Hypothesis
A minimally invasive 'step-up approach' will lead to a reduction of postoperative major morbidity and mortality in patients with infected (peri-)pancreatic necrosis.
Conclusion
The PANTER trial aims to compare a minimally invasive 'step-up approach' with maximal necrosectomy to determine which is more effective in reducing complications in patients with infected necrotizing pancreatitis.
Supporting Evidence
- The study aims to provide evidence for the effectiveness of a minimally invasive approach compared to traditional surgery.
- Previous studies indicated high mortality rates with traditional necrosectomy methods.
- The trial is designed to assess both major morbidity and mortality rates.
Takeaway
This study is trying to find out if a gentler way to treat a serious pancreas problem is better than the usual surgery.
Methodology
88 patients will be randomly assigned to either a minimally invasive 'step-up approach' or maximal necrosectomy, with outcomes measured over a 3-year period.
Potential Biases
Selection bias may influence results due to the nature of patient recruitment and treatment protocols.
Limitations
The study may face challenges in patient recruitment due to the rarity of the condition and strict inclusion criteria.
Participant Demographics
Patients aged 18 and older with suspected infected necrotizing pancreatitis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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