Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling
2008
How Osteoclasts Help Osteoblasts Move
publication
Evidence: moderate
Author Information
Author(s): Sanchez-Fernandez Maria Arantzazu, Gallois Anne, Riedl Thilo, Jurdic Pierre, Hoflack Bernard
Primary Institution: Biotechnological Center, Dresden University of Technology, Dresden, Germany
Hypothesis
Can osteoclasts control the movement of osteoblasts?
Conclusion
Mature osteoclasts control the movement of osteoblasts through a specific signaling pathway.
Supporting Evidence
- Mature osteoclasts secrete PDGF-bb, which attracts osteoblasts.
- Knockdown of PDGF-bb reduces the ability of osteoclasts to attract osteoblasts.
- PDGFR-β is the receptor on osteoblasts that binds PDGF-bb.
Takeaway
Osteoclasts, which break down bone, can also help osteoblasts, which build bone, to move to where they are needed.
Methodology
In vitro cell systems were used to study the signaling between osteoclasts and osteoblasts.
Limitations
The study was conducted in vitro, which may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.00001
Statistical Significance
p<0.00001
Digital Object Identifier (DOI)
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