Effects of multidomain lifestyle intervention on frailty among older men and women – a secondary analysis of a randomized clinical trial
2025

Effects of Lifestyle Changes on Frailty in Older Adults

Sample size: 1259 publication 10 minutes Evidence: moderate

Author Information

Author(s): Saarela Laura, Lehtisalo Jenni, Ngandu Tiia, Kyrönlahti Saila, Havulinna Satu, Strandberg Timo, Levälahti Esko, Antikainen Riitta, Soininen Hilkka, Tuomilehto Jaakko, Laatikainen Tiina, Kivipelto Miia, Kulmala Jenni

Primary Institution: Finnish Institute for Health and Welfare (THL)

Hypothesis

The study aimed to investigate the efficacy of a 2-year multidomain lifestyle intervention in preventing and reversing frailty among older adults at risk of cognitive disorders.

Conclusion

The study found that a multidomain lifestyle intervention may help reverse early signs of frailty among older men, particularly by increasing physical activity.

Supporting Evidence

  • Older men in the intervention group had a higher probability of being non-frail after the intervention compared to the control group.
  • The intervention was particularly effective in increasing physical activity among men.
  • Women did not show significant changes in frailty status from the intervention.

Takeaway

This study shows that older men can become less frail by changing their lifestyle, like exercising more and eating better.

Methodology

The study was a 2-year randomized controlled trial involving nutritional counseling, physical exercise, cognitive training, and social activities among older adults.

Potential Biases

Participants were relatively healthy, which may limit the generalizability of the results.

Limitations

The study's definition of frailty may not be sensitive enough for a relatively healthy population, and the small number of frail individuals limited statistical power.

Participant Demographics

Participants were aged 60-77 years, with 45% women.

Statistical Information

P-Value

0.040

Confidence Interval

95% CI for difference not specified

Statistical Significance

p=0.040

Digital Object Identifier (DOI)

10.1080/07853890.2024.2446699

Want to read the original?

Access the complete publication on the publisher's website

View Original Publication