Phellinus linteus suppresses growth, angiogenesis and invasive behaviour of breast cancer cells through the inhibition of AKT signalling
2008
Phellinus linteus and Breast Cancer
publication
Evidence: high
Author Information
Author(s): Sliva D, Jedinak A, Kawasaki J, Harvey K, Slivova V
Primary Institution: Cancer Research Laboratory, Methodist Research Institute
Hypothesis
Inhibition of AKT signalling by Phellinus mushroom.
Conclusion
Phellinus linteus shows potential therapeutic effects against invasive breast cancer by inhibiting growth, angiogenesis, and invasive behavior of cancer cells.
Supporting Evidence
- Phellinus linteus inhibits proliferation of breast cancer cells.
- PL suppresses invasive behavior of breast cancer cells.
- PL inhibits angiogenesis by reducing VEGF secretion.
Takeaway
A mushroom called Phellinus linteus can help stop breast cancer cells from growing and spreading by blocking certain signals in the cells.
Methodology
The study evaluated the effects of Phellinus linteus on breast cancer cells through various assays including cell proliferation, migration, invasion, and angiogenesis.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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