Prognostic Value of tPA and its Complex in Breast Cancer
Author Information
Author(s): Witte J H de, Sweep C G J, Klijn J G M, Grebenschikov N, Peters H A, Look M P, Tienoven ThH van, Heuvel J J T M, Vries J Bolt-De, Benraad ThJ, Foekens J A
Primary Institution: Department of Chemical Endocrinology, University Hospital Nijmegen
Hypothesis
The study investigates whether the tPA:PAI-1 complex provides prognostic information in breast cancer patients.
Conclusion
The tPA:PAI-1 complex levels in cytosols are associated with poor survival outcomes, while total tPA levels in pellet extracts are linked to better survival.
Supporting Evidence
- Statistically significant correlations were found between cytosolic levels and those in pellet extracts.
- Elevated levels of total tPA in pellet extracts were associated with prolonged relapse-free and overall survival.
- High levels of the tPA:PAI-1 complex in cytosols were linked to poor relapse-free and overall survival.
- The prognostic information from the tPA:PAI-1 complex was comparable to that from total PAI-1.
Takeaway
This study found that certain proteins in breast cancer patients can help predict how long they might live without their cancer coming back.
Methodology
The study used enzyme-linked immunosorbent assay (ELISA) to measure tPA and its complex with PAI-1 in patient samples.
Participant Demographics
Patients with primary breast cancer.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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