Plasma Amino Acid Profiles of Cancer Patients for Early Detection
Author Information
Author(s): Miyagi Yohei, Higashiyama Masahiko, Gochi Akira, Akaike Makoto, Ishikawa Takashi, Miura Takeshi, Saruki Nobuhiro, Bando Etsuro, Kimura Hideki, Imamura Fumio, Moriyama Masatoshi, Ikeda Ichiro, Chiba Akihiko, Oshita Fumihiro, Imaizumi Akira, Yamamoto Hiroshi, Miyano Hiroshi, Horimoto Katsuhisa, Tochikubo Osamu, Mitsushima Toru, Yamakado Minoru, Okamoto Naoyuki
Primary Institution: Kanagawa Cancer Center, Yokohama, Japan
Hypothesis
The study aims to determine the characteristics of plasma free amino acid (PFAA) profiles in cancer patients and their potential for early detection.
Conclusion
PFAA profiling shows promise for improving cancer screening and diagnosis, even in early-stage patients.
Supporting Evidence
- Significant differences in PFAA profiles were found between cancer patients and controls.
- Multivariate analysis showed high accuracy in distinguishing cancer patients from controls.
- Alterations in PFAA profiles were observed even in early-stage cancer patients.
- The study included a large sample size, enhancing the robustness of the findings.
- Common metabolic changes were identified across different types of cancer.
Takeaway
Doctors can use a simple blood test to check for certain amino acids that might help find cancer early.
Methodology
Plasma samples from approximately 200 cancer patients were analyzed using high-performance liquid chromatography and mass spectrometry.
Potential Biases
Potential biases may arise from the case-control study design.
Limitations
The study is a case-control design, and further validation with larger cohorts is needed.
Participant Demographics
Patients included those with lung, gastric, colorectal, breast, or prostate cancer, with a mean age of around 65 years.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 0.766∼0.838
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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