N-Acetylcysteine Supplementation and Exercise in Sedentary Men
Author Information
Author(s): Donrawee Leelarungrayub, Khansuwan Raphiphat, Pothongsunun Prapas, Klaphajone Jakkrit
Primary Institution: Chiang Mai University
Hypothesis
Does short-term N-acetylcysteine supplementation affect muscle fatigue and oxidative stress during exercise in sedentary men?
Conclusion
N-acetylcysteine supplementation helps protect against muscle fatigue and maintains total antioxidant capacity after exercise, but does not influence creatine kinase and tumor necrotic factor-alpha levels.
Supporting Evidence
- N-acetylcysteine improved the fatigue index in the supplement group after 7 days.
- VO2max increased significantly in the supplement group after supplementation.
- Total antioxidant capacity levels did not decrease after exercise in the supplement group.
Takeaway
Taking N-acetylcysteine for a week can help your muscles not get as tired when you exercise, but it doesn't change some other things in your body.
Methodology
The study involved 29 sedentary men who were randomly assigned to either a control or a NAC supplement group, with assessments before and after a 7-day supplementation period.
Limitations
The study did not evaluate NAC levels in plasma and had a small sample size.
Participant Demographics
Healthy, nonsmoking, nonathletic males aged 20-24 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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