Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury
2012
Inflammatory Mechanisms of Organ Crosstalk during Ischemic Acute Kidney Injury
publication
Author Information
Author(s): Laura E. White, Heitham T. Hassoun
Primary Institution: The Methodist Hospital and Research Institute
Hypothesis
The study examines the influence of kidney ischemia-reperfusion injury on systemic inflammation and distant organ injury.
Conclusion
Ischemic acute kidney injury initiates a cascade of proinflammatory pathways that facilitate organ crosstalk and remote organ injury.
Supporting Evidence
- Acute kidney injury is a common complication during hospitalization with high mortality rates.
- Kidney ischemia-reperfusion injury activates a proinflammatory cascade affecting distant organs.
- Recent data highlights the importance of both innate and adaptive immune responses in organ injury.
Takeaway
When the kidneys are injured, they can cause problems in other organs too, making people very sick. This study looks at how this happens.
Digital Object Identifier (DOI)
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