Chitosan-Coated Lipid Vesicles for Indomethacin Delivery
Author Information
Author(s): Abu Koush Angy, Popa Eliza Gratiela, Pricop Daniela Angelica, Nita Loredana, Foia Cezar-Ilie, Pauna Ana-Maria Raluca, Buca Beatrice Rozalina, Pavel Liliana Lacramioara, Mititelu-Tartau Liliana
Primary Institution: ‘Grigore T. Popa’ University of Medicine and Pharmacy, Iasi, Romania
Hypothesis
This study seeks to develop and characterize novel lipid vesicles composed of phosphatidylcholine and chitosan that encapsulate indomethacin and evaluate their in vitro hemocompatibility.
Conclusion
Chitosan-coated lipid vesicles provide a promising approach for modified indomethacin delivery, enhancing stability and hemocompatibility.
Supporting Evidence
- The IND-ves exhibited an entrapment efficiency of 85%.
- The vesicles averaged 317.6 nm in size.
- The Zeta potential of the vesicles was 24 mV, indicating good stability.
- In vitro release kinetics demonstrated an extended release profile of IND from the vesicles over 8 hours.
- The hemocompatibility assessment revealed minimal hemolysis, comparable to control groups.
Takeaway
Researchers made tiny bubbles called vesicles to carry a medicine called indomethacin, which helps with pain. These bubbles are special because they are coated with a material that makes them safer and better at delivering the medicine.
Methodology
The vesicles were prepared using a molecular droplet self-assembly technique and characterized for size, morphology, Zeta potential, and encapsulation efficiency.
Limitations
Further in vivo studies are required to explore clinical applications.
Participant Demographics
Healthy, genetically unmodified, three-month-old male Swiss mice.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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