Bifidobacterium Composition in Coeliac Disease
Author Information
Author(s): Collado Maria Carmen, Donat Ester, Ribes-Koninckx Carmen, Calabuig Miguel, Sanz Yolanda
Primary Institution: Institute of Agrochemistry and Food Technology (IATA), Spanish National Research Council (CSIC)
Hypothesis
The study aims to assess the relationships between gut bifidobacteria composition and coeliac disease in children.
Conclusion
Reductions in total Bifidobacterium and B. longum populations were associated with both active and non-active coeliac disease when compared to controls.
Supporting Evidence
- Active and non-active CD patients showed lower numbers of total Bifidobacterium and B. longum species in faeces and duodenal biopsies than controls.
- B. catenulatum prevalence was higher in biopsies of controls than in those of active and non-active CD patients.
- B. dentium prevalence was higher in faeces of non-active CD patients than in controls.
Takeaway
Kids with coeliac disease have fewer good bacteria in their tummies compared to healthy kids, which might help explain their sickness.
Methodology
Faecal samples and duodenal biopsies from children with active and non-active coeliac disease and controls were analyzed using real-time PCR.
Limitations
The study had a limited number of biopsy samples compared to faecal samples.
Participant Demographics
Children with active and non-active coeliac disease and age-matched controls.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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