RNF11 Protein in Breast Cancer
Author Information
Author(s): Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger A M, Seth A
Primary Institution: Sunnybrook and Women's College Health Sciences Centre, University of Toronto
Hypothesis
Is RNF11 overexpressed in breast cancer and does it interact with Smurf2 E3 ligase?
Conclusion
RNF11 is overexpressed in breast cancer and interacts with Smurf2, affecting TGFβ signaling.
Supporting Evidence
- RNF11 protein expression was monitored in 125 primary tumors using immunohistochemistry.
- Over 90% of invasive breast cancer cases showed strong RNF11 expression.
- RNF11 interacts with Smurf2 through its PY motif, which is essential for this interaction.
Takeaway
This study found that a protein called RNF11 is found in high amounts in breast cancer cells and helps another protein, Smurf2, work better.
Methodology
The study used immunohistochemistry on a tissue microarray of 125 primary tumors to assess RNF11 expression.
Participant Demographics
The study included 125 human primary tumors from various types, including breast, prostate, and colon cancers.
Digital Object Identifier (DOI)
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