Comparing Ciclesonide to Other Inhaled Corticosteroids for Asthma
Author Information
Author(s): Matthew J Dyer, David MG Halpin, Ken Stein
Primary Institution: Peninsula Medical School, University of Exeter, UK
Hypothesis
How does the effectiveness and safety of ciclesonide compare to other inhaled corticosteroids in adults with chronic asthma?
Conclusion
Ciclesonide shows similar effectiveness to other inhaled corticosteroids, but the evidence is limited and inconclusive.
Supporting Evidence
- Five studies met the inclusion criteria for the review.
- Methodological quality of the studies was variable.
- No significant differences were found between ciclesonide and other corticosteroids in terms of lung function or symptoms.
- One trial showed less cortisol suppression with ciclesonide compared to fluticasone.
Takeaway
This study looked at a new asthma medicine called ciclesonide and found it works about the same as older medicines, but we need more research to be sure.
Methodology
Systematic review of randomized controlled trials comparing ciclesonide to other inhaled corticosteroids.
Potential Biases
Most studies were sponsored by pharmaceutical companies, which may introduce bias.
Limitations
The studies included were small and of low power, limiting the reliability of the findings.
Participant Demographics
Adults aged 18 and over with chronic asthma.
Statistical Information
P-Value
P < 0.05 for cortisol suppression comparison.
Confidence Interval
95% CI for various outcomes reported.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website