Neuropeptide growth factors and cancer
1991
Neuropeptide Growth Factors and Cancer
publication
Evidence: moderate
Author Information
Author(s): P.J. Woll
Primary Institution: CRC Department of Medical Oncology, Christie Hospital
Hypothesis
Neuropeptides may act as important mitogens in cancer growth.
Conclusion
Neuropeptides are recognized as significant regulators of tumor growth, particularly in small cell lung cancer.
Supporting Evidence
- Neuropeptides can act as growth factors in various cancers.
- Bombesin/GRP has been shown to stimulate growth in small cell lung cancer.
- Gastrin has been implicated in the growth of gastric and colonic adenocarcinomas.
- Cholecystokinin has trophic effects on the pancreas and can stimulate growth in gastric cancer cells.
- Neurotensin may act as an autocrine growth factor for small cell lung cancer.
Takeaway
Some tiny molecules called neuropeptides can help cancer cells grow. Scientists are studying how these molecules work to find better treatments.
Methodology
The review discusses various neuropeptides and their roles in cancer growth, particularly focusing on their mechanisms and effects in vitro and in vivo.
Limitations
The review is based on existing literature and may not include the latest findings or all possible neuropeptides.
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