CDK-inhibitor independent cell cycle progression in an experimental haematopoietic stem cell leukaemia despite unaltered Rb-phosphorylation
1999
Cell Cycle Progression in Stem Cell Leukaemia
publication
Evidence: moderate
Author Information
Author(s): Huss R, Theis S, Deeg H J
Primary Institution: Institute of Pathology, University of Munich
Hypothesis
Can MHC class II gene expression affect cell cycle progression in haematopoietic stem cell leukaemia?
Conclusion
The study found that MHC class II gene expression allows stem cell leukaemia cells to grow independently of normal cell cycle controls.
Supporting Evidence
- MHC class II gene expression leads to changes in cell morphology and accelerated cell cycle progression.
- Transfected cells show features of immature stem cell leukaemia.
- Normal cell cycle controls are disrupted in the presence of MHC class II genes.
Takeaway
Some blood cells can grow and divide without following the usual rules, which might help them become cancerous.
Methodology
The study involved transfecting a canine progenitor cell line with MHC class II genes and observing changes in cell behavior.
Digital Object Identifier (DOI)
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