Dopamine transporter genotype and executive function in children with ADHD
Author Information
Author(s): Karama Sherif, Grizenko Natalie, Sonuga-Barke Edmund, Doyle Alysa, Biederman Joseph, Mbekou Valentin, Polotskaia Anna, Ter-Stepanian Marina, De Guzman Rosherrie, Bellingham Johanne, Sengupta Sarojini, Joober Ridha
Primary Institution: McGill University
Hypothesis
DAT1 gene genotype has an effect on executive function performance.
Conclusion
The study found that children with the 9/10 genotype generally performed worse on executive function tasks compared to those with the 10/10 genotype.
Supporting Evidence
- Children with the 9/10 genotype exhibited poorer performance on executive function tasks.
- Significant effects were found on the Tower of London and WISC-III Freedom From Distractibility Index.
- No effect of genotype was detected on Wisconsin Card Sorting Test measures.
Takeaway
Kids with a certain gene type (9/10) did worse on thinking tasks than kids with another type (10/10).
Methodology
196 children with ADHD were genotyped and tested using neuropsychological tests to assess executive function.
Limitations
The sample mainly included children with combined type ADHD, limiting analysis of other subtypes.
Participant Demographics
Children aged 6 to 12 years diagnosed with ADHD.
Statistical Information
P-Value
0.009
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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