Hormone Levels and Migration History in Asian-American Women
Author Information
Author(s): Falk R T, Fears T R, Hoover R N, Pike M C, Wu A H, Nomura A M Y, Kolonel L N, West D W, Ziegler R G
Primary Institution: Division of Cancer Epidemiology and Genetics, National Cancer Institute
Hypothesis
Does place of birth influence endogenous hormone levels in Asian-American women?
Conclusion
The study found that androgens, particularly DHEA, were lower in Western-born Asian women, while estrogen levels did not significantly differ based on place of birth.
Supporting Evidence
- Women born in the West had lower levels of DHEA compared to those born in the East.
- Estrogen levels did not significantly differ between Asian- and Western-born women.
- Participation rates for blood collection were higher among more westernised women.
- Among premenopausal women, those least westernised had the lowest levels of E1, E2, and E1S.
Takeaway
This study looked at how where Asian-American women were born affects their hormone levels. It found that women born in the West had lower levels of certain hormones compared to those born in Asia.
Methodology
A population-based case-control study measuring hormone levels in plasma from premenopausal and postmenopausal Asian-American women.
Potential Biases
Participation in the blood collection was influenced by a woman's degree of westernisation.
Limitations
The small number of women in the most extreme categories of migration history limited the ability to explore differences in hormone levels.
Participant Demographics
Women of Chinese, Japanese, or Filipino descent, aged 20–55 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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