Anti-CCP Antibodies in Primary Sjögren Syndrome and Synovitis
Author Information
Author(s): Atzeni Fabiola, Sarzi-Puttini Piercarlo, Lama Nicola, Bonacci Eleonora, Bobbio-Pallavicini Francesca, Montecucco Carlomaurizio, Caporali Roberto
Primary Institution: Rheumatology Unit, L. Sacco Hospital, University of Milan
Hypothesis
The study investigates the prevalence of anti-CCP antibodies in patients with primary Sjögren syndrome and their correlation with clinical and laboratory data.
Conclusion
A minority of patients with primary Sjögren syndrome are anti-CCP-positive, and this positivity is closely associated with the prevalence of synovitis.
Supporting Evidence
- 14 patients (9.9%) had moderate to high levels of anti-CCP.
- 94 patients (66.7%) were positive for RF.
- 81 patients (57.4%) showed extra-glandular involvement.
- 44 patients (31.2%) had synovitis without any radiographic sign of erosion.
- There was a close correlation between the presence of anti-CCP and synovitis (P < 0.001).
- Multivariate analysis confirmed the association between anti-CCP and increased prevalence of synovitis.
Takeaway
Some people with a condition called primary Sjögren syndrome have a specific antibody that might mean they have joint swelling, but not everyone with this condition has that antibody.
Methodology
The study analyzed clinical and serological data of 155 patients with primary Sjögren syndrome, excluding those with rheumatoid arthritis, and assessed the presence of synovitis and extra-glandular involvement.
Limitations
The study excluded patients with rheumatoid arthritis, which may limit the generalizability of the findings.
Participant Demographics
141 patients (27 males and 114 females; mean age 48 years, range 39 to 60).
Statistical Information
P-Value
0.010
Confidence Interval
1.475 to 74.870
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website