Tumor-Derived Syndecan-1 Mediates Distal Cross-Talk with Bone that Enhances Osteoclastogenesis
2010
Tumor-Derived Syndecan-1 and Bone Destruction
Sample size: 9
publication
10 minutes
Evidence: high
Author Information
Author(s): Kelly Thomas, Suva Larry J, Nicks Kristy M, MacLeod Veronica, Sanderson Ralph D
Primary Institution: University of Arkansas for Medical Sciences
Hypothesis
Does syndecan-1 shed by tumor cells enhance osteoclastogenesis and bone resorption?
Conclusion
Syndecan-1 shed by tumor cells enhances osteoclastogenesis and contributes to bone destruction.
Supporting Evidence
- Syndecan-1 was shown to significantly stimulate human osteoclastogenesis in vitro.
- Animals bearing heparanase-high tumors had significantly higher numbers of osteoclasts compared to those with low levels.
- Conditioned medium from heparanase-high cells enhanced osteoclastogenesis compared to heparanase-low cells.
Takeaway
When cancer cells release a substance called syndecan-1, it helps special cells called osteoclasts break down bone, which can make the cancer spread more.
Methodology
The study involved in vitro osteoclastogenesis assays and histomorphometric analysis of bones from tumor-bearing mice.
Participant Demographics
Female SCID mice were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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