Differential expression of a novel serine protease homologue in squamous cell carcinoma of the head and neck
2001
Study of a New Gene in Head and Neck Cancer
Sample size: 12
publication
Evidence: moderate
Author Information
Author(s): Lang J C, Schuller D E
Primary Institution: The Ohio State University
Hypothesis
Differential gene expression between squamous cell carcinoma of the head and neck and matched normal tissue is present.
Conclusion
The study found that the novel gene DESC1 is significantly reduced or absent in most squamous cell carcinoma tissues compared to normal tissues.
Supporting Evidence
- DESC1 expression is reduced or absent in 11 out of 12 squamous cell carcinoma tissue specimens compared to matched normal tissue.
- DESC1 can only be detected in tissues from the head and neck, skin, prostate, and testes.
- DESC1 expression is epithelial-specific according to cell line studies.
- DESC1 is located on the long arm of chromosome 4 at position q12–13.
Takeaway
Researchers looked at a new gene in cancer from the head and neck and found it was mostly missing in the cancer tissues.
Methodology
Representational Difference Analysis was used to study gene expression.
Digital Object Identifier (DOI)
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