Acute and cumulative effects of carboplatin on renal function
1989
Effects of Carboplatin on Kidney Function
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): D.Th. Sleijfer, E.F. Smit, S. Meijer, N.H. Mulder, P.E. Postmus
Primary Institution: University Hospital Groningen
Hypothesis
Does carboplatin cause nephrotoxicity in lung cancer patients?
Conclusion
Carboplatin causes a significant loss of renal function after multiple treatment courses.
Supporting Evidence
- After the second course of treatment, a significant decrease in GFR and ERPF was observed.
- Median decrease in GFR was 19.0% after five courses.
- Statistical analysis showed significant differences in renal function after multiple courses of carboplatin.
Takeaway
Carboplatin can hurt your kidneys, especially if you take it many times.
Methodology
The study measured renal function using radioisotope clearance methods in lung cancer patients treated with carboplatin and vincristine.
Limitations
The study had a small sample size and limited follow-up duration for monitoring renal function.
Participant Demographics
10 patients (1 female, 9 male) aged 48 to 69 with untreated lung cancer.
Statistical Information
P-Value
p<0.02
Statistical Significance
p<0.05
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