Autocrine and paracrine motility factors and their involvement in invasiveness in a human oral carcinoma cell line
1999
Cell Motility Factors in Oral Cancer
publication
Evidence: moderate
Author Information
Author(s): Hasina R, Matsumoto K, Matsumoto-Taniura N, Kato I, Sakuda M, Nakamura T
Primary Institution: Osaka University
Hypothesis
The study investigates the role of autocrine and paracrine motility factors in the invasiveness of a human oral carcinoma cell line.
Conclusion
The study found that IF cells utilize TGF-α and TGF-β1 as autocrine motility factors and HGF as a paracrine motility factor, enhancing their invasiveness.
Supporting Evidence
- Conditioned medium from IF cells stimulated cell scattering and migration of GB-d1 gallbladder carcinoma cells.
- Antibodies against TGF-α and TGF-β1 inhibited autonomous migration of the IF cells.
- In vitro invasion of IF cells was strongly enhanced by hepatocyte growth factor (HGF).
- The conditioned medium from fibroblasts enhanced in vitro invasion of IF cells.
- IF cells secreted a factor inducing HGF production in fibroblasts, identified as interleukin-1.
Takeaway
Cancer cells can move and invade more easily because of special signals they send out, which help them interact with other cells.
Methodology
The study used a newly established human cell line from oral squamous cell carcinoma to investigate the effects of various motility factors.
Digital Object Identifier (DOI)
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