Maternal Serum Amyloid A and Preterm Birth
Author Information
Author(s): Muacevic Alexander, Adler John R, Chiriac Evelina, Popa Zoran L, Gorun Florin I, Vilceanu Narcis, Oros Razvan, Buhas Liana-Camelia, Dumitrescu Patrick, Citu Cosmin, Tivadar Katalin Midia, Csep Andrei, Buhas Bogdan Adrian
Primary Institution: Timisoara Municipal Emergency Clinical Hospital
Hypothesis
The study aims to evaluate the value of maternal serum amyloid A (SAA) level as a predictive marker for preterm delivery.
Conclusion
Maternal SAA proved to be a strong independent risk factor for preterm birth.
Supporting Evidence
- Maternal SAA levels were significantly higher in the preterm group (22 mg/L) compared to the term group (7 mg/L).
- The ROC curve analysis yielded a moderate predictive value of SAA for preterm birth, with an AUC of 0.690.
- Elevated SAA levels were associated with a 27.89-fold increased risk of preterm delivery.
- After adjusting for maternal age and medical conditions, elevated SAA remained a significant predictor of preterm birth.
Takeaway
This study found that higher levels of a protein called SAA in pregnant women can help predict if they might give birth early.
Methodology
This observational study enrolled 136 pregnant women and analyzed maternal serum amyloid A levels to assess their association with preterm birth.
Potential Biases
Selection and information biases were mitigated through strict inclusion criteria and standardized data collection.
Limitations
The study was conducted at a single center, which may limit generalizability, and there may be unmeasured confounders affecting the results.
Participant Demographics
Participants were pregnant women aged 18-40, with singleton pregnancies, admitted for delivery.
Statistical Information
P-Value
0.001
Confidence Interval
95% CI: 0.600-0.780
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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