4-(3-Fluoro-4-nitrophenyl)morpholin-3-one
2011
Study of 4-(3-Fluoro-4-nitrophenyl)morpholin-3-one
publication
Evidence: moderate
Author Information
Author(s): Huang Chang-Jiang, Wu Jiang, Cai Zhi-Qiang, Yuan Jing
Primary Institution: Tianjin Institute of Pharmaceutical Research
Hypothesis
The title compound is an important intermediate in the preparation of derivatives of the factor Xa inhibitor rivaroxaban.
Conclusion
The crystal structure of the title compound was successfully determined, revealing its unique conformation and hydrogen bonding.
Supporting Evidence
- The title compound is an intermediate in the preparation of rivaroxaban derivatives.
- The morpholinone ring adopts a twist-chair conformation.
- Molecules are linked by intermolecular hydrogen bonds into a chain.
Takeaway
This study looks at a chemical compound that helps make a medicine to prevent blood clots, showing how it is structured.
Methodology
The compound was synthesized and its crystal structure was analyzed using X-ray diffraction.
Digital Object Identifier (DOI)
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