Aspirin induces cell death and caspase-dependent phosphatidylserine externalization in HT-29 human colon adenocarcinoma cells
1999
Aspirin and Colon Cancer Cells
publication
Author Information
Author(s): Castaño E, Dalmau M, Barragán M, Pueyo G, Bartrons R, Gil J
Primary Institution: Unitat de Bioquímica, Departament de Ciències Fisiològiques II, Universitat de Barcelona
Hypothesis
Does aspirin induce cell death in HT-29 human colon adenocarcinoma cells?
Conclusion
Aspirin induces cell death in HT-29 colon carcinoma cells through apoptosis, but with atypical features.
Supporting Evidence
- Aspirin induced nuclear chromatin condensation and phosphatidylserine externalization.
- The effect of aspirin on Annexin V binding was inhibited by the caspase inhibitor Z-VAD.fmk.
- Aspirin did not induce oligonucleosomal fragmentation of DNA or decrease in DNA content.
Takeaway
Aspirin can make cancer cells die, but it does it in a different way than we usually expect.
Methodology
The study analyzed the effects of aspirin on HT-29 colon carcinoma cells, focusing on apoptosis markers.
Digital Object Identifier (DOI)
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