Epigenetic regulation of caloric restriction in aging
2011
Epigenetic Regulation of Caloric Restriction in Aging
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Li Yuanyuan, Daniel Michael, Tollefsbol Trygve O
Primary Institution: University of Alabama at Birmingham
Hypothesis
How does caloric restriction affect aging through epigenetic mechanisms?
Conclusion
Understanding the role of epigenetics in caloric restriction may lead to new strategies for preventing aging-related diseases.
Supporting Evidence
- Caloric restriction has been shown to extend lifespan in various animal models.
- Epigenetic mechanisms like DNA methylation and histone modification play crucial roles in aging.
- Caloric restriction can delay aging-associated diseases such as cancer and diabetes.
Takeaway
Eating less can help us live longer by changing how our genes work without changing the genes themselves.
Methodology
This review assesses current advances in epigenetic regulation in response to caloric restriction and its effects on aging.
Limitations
The majority of research has been based on animal studies, with limited human data.
Digital Object Identifier (DOI)
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