Prevalence of Carbapenemase-Producing Enterobacteriaceae in Argentina Post-COVID-19
Author Information
Author(s): Echegorry Mariano, Marchetti Paulina, Sanchez Cristian, Olivieri Laura, Faccone Diego, Martino Florencia, Sarkis Badola Tomas, Ceriana Paola, Rapoport Melina, Lucero Celeste, Albornoz Ezequiel, Corso Alejandra, Pasteran Fernando
Primary Institution: Servicio Antimicrobianos, National Reference Laboratory in Antimicrobial Resistant, National Institute of Infectious Diseases (INEI), Administración Nacional de Laboratorios e Institutos de Salud (ANLIS) “Dr. Carlos G Malbrán”
Hypothesis
What is the prevalence of carbapenemase-producing Enterobacterales in Argentina during the post-COVID-19 pandemic period?
Conclusion
The study found a significant rise in the prevalence of NDM and KPC carbapenemases, with Klebsiella pneumoniae being the primary species responsible for their dissemination.
Supporting Evidence
- Metallo-β-lactamase (MBL) and KPC accounted for 81.8% of carbapenemases identified.
- Klebsiella pneumoniae represented 76% of the isolates.
- High activity of aztreonam-avibactam against MBLs was observed.
- NDM and KPC carbapenemases are now circulating at equivalent levels in Argentina.
- Secondary ESBL or plasmidic AmpC production was identified in 64.9% of carbapenemase producers.
- Susceptibility rates for older antibiotics were significantly lower compared to newer agents.
- Diagnostic accuracy for carbapenemase detection was high at 89.5%.
Takeaway
This study looked at how many germs that resist antibiotics are in hospitals in Argentina after COVID-19, and it found that some germs are becoming more common and harder to treat.
Methodology
A prospective, multicenter study involving 182 hospitals that submitted Enterobacterales clinical isolates to the National Reference Laboratory.
Potential Biases
Potential bias due to the limited number of hospitals participating and the geographic concentration of those hospitals.
Limitations
The study may not capture seasonal variability, most hospitals were in densely populated areas, and only half of the high-complexity hospitals participated.
Participant Demographics
The study included isolates from various hospitals across all 24 jurisdictions in Argentina.
Statistical Information
P-Value
p<0.00001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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