Reelin Controls Progenitor Cell Migration in the Healthy and Pathological Adult Mouse Brain
Author Information
Author(s): Courtès Sandrine, Vernerey Julien, Pujadas Lluís, Magalon Karine, Cremer Harold, Soriano Eduardo, Durbec Pascale, Cayre Myriam
Primary Institution: Institut de Biologie du Développement de Marseille Luminy, CNRS, Université de la Méditerranée, Marseille, France
Hypothesis
Understanding the signals that control migration of neural progenitor cells in the adult brain may provide new therapeutic opportunities.
Conclusion
Reelin is a key player in post-lesional cell migration in the adult brain and may promote myelin repair.
Supporting Evidence
- Reelin is upregulated around lesions in the adult brain.
- Experimental increase of Reelin in healthy brains changes the migratory behavior of progenitor cells.
- Reelin promotes cell detachment and migration towards demyelination lesions.
Takeaway
Reelin helps brain cells move to where they are needed, especially after an injury, which could help heal the brain.
Methodology
The study used in vivo and in vitro experiments to analyze the effects of Reelin on neural progenitor cell migration and behavior.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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