T Cell Responses to Malaria Vaccines in Ghanaian Children
Author Information
Author(s): Ansong Daniel, Asante Kwaku P., Vekemans Johan, Owusu Sandra K., Owusu Ruth, Brobby Naana A. W., Dosoo David, Osei-Akoto Alex, Osei-Kwakye Kingsley, Asafo-Adjei Emmanuel, Boahen Kwadwo O., Sylverken Justice, Adjei George, Sambian David, Apanga Stephen, Kayan Kingsley, Janssens Michel H., Lievens Marc J. J., Olivier Aurelie C., Jongert Erik, Dubois Patrice, Savarese Barbara M., Cohen Joe, Antwi Sampson, Greenwood Brian M., Evans Jennifer A., Agbenyega Tsiri, Moris Philippe J., Owusu-Agyei Seth
Primary Institution: School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana
Hypothesis
The study aims to evaluate the safety and immunogenicity of RTS,S/AS01E and RTS,S/AS02D malaria vaccines administered according to different schedules in children aged 5–17 months.
Conclusion
The findings support further Phase III evaluation of RTS,S/AS01E, indicating that different immunization schedules can affect T cell responses.
Supporting Evidence
- RTS,S/AS01E induced higher CD4 T cell responses compared to RTS,S/AS02D.
- Three-dose schedules induced higher antibody levels than two-dose schedules.
- Safety and immunogenicity evaluations showed both vaccines were well tolerated.
Takeaway
This study tested two malaria vaccines in young children to see how well they work and if they are safe. It found that one vaccine worked better with a specific schedule.
Methodology
The study was a Phase II randomized, controlled, partially-blind trial evaluating three vaccination schedules over 19 months.
Potential Biases
Potential bias may arise from the controlled nature of the trial and the involvement of the vaccine manufacturer in the study.
Limitations
The study was limited to two research centers in Ghana, which may affect the generalizability of the results.
Participant Demographics
Children aged 5–17 months from two research centers in Ghana.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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