Antioxidant Effects and Potential Mechanisms of Citrus reticulata ‘Chachi’ Components: An Integrated Approach of Network Pharmacology and Metabolomics
2024

Antioxidant Effects of Citrus reticulata ‘Chachi’ Components

Sample size: 24 publication 10 minutes Evidence: high

Author Information

Author(s): Xiao Jiahao, Sun Tian, Jiang Shengyu, Xiao Zhiqiang, Shan Yang, Li Tao, Pan Zhaoping, Li Qili, Fu Fuhua, De Santis Diana, Modesti Margherita

Primary Institution: Hunan Agriculture Product Processing Institute, Hunan Academy of Agricultural Sciences, Changsha, China

Hypothesis

This research investigates the metabolic distinctions and antioxidant properties across different parts of Citrus reticulata ‘Chachi’.

Conclusion

The study found significant metabolic differences among the parts of Citrus reticulata ‘Chachi’, with the dried mature peel showing the highest antioxidant properties.

Supporting Evidence

  • The study identified 1622 differentially expressed metabolites across the Citrus parts.
  • CP exhibited the highest total phenolic content and antioxidant activity.
  • Flavonoids such as nobiletin and tangeretin were most abundant in the peel.
  • PU and PWS contained higher levels of flavonoids, particularly hesperidin.
  • Network pharmacology analysis predicted key targets for antioxidant effects.

Takeaway

Different parts of the Citrus fruit have different health benefits, and the peel is the best for fighting bad stuff in our bodies.

Methodology

The study used metabolomic analysis and network pharmacology to assess the antioxidant properties and metabolic differences of Citrus reticulata ‘Chachi’.

Limitations

Further studies in animal models are needed to validate the in vivo bioactivity of the components.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/foods13244018

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