PROTAC-DB 3.0: an updated database of PROTACs with extended pharmacokinetic parameters
2025
PROTAC-DB 3.0: An Updated Database of PROTACs
publication
Evidence: high
Author Information
Author(s): Ge Jingxuan, Li Shimeng, Weng Gaoqi, Wang Huating, Fang Meijing, Sun Huiyong, Deng Yafeng, Hsieh Chang-Yu, Li Dan, Hou Tingjun
Primary Institution: Zhejiang University
Conclusion
The updated PROTAC-DB 3.0 includes 6111 PROTACs and enhanced pharmacokinetic data to aid in drug design.
Supporting Evidence
- The database now contains 6111 PROTACs, a significant increase from the previous version.
- Pharmacokinetic data has been incorporated to assist in the rational design of PROTACs.
- New features for sorting by molecular similarity and publication date have been added to enhance user experience.
Takeaway
This study created a new version of a database that helps scientists find information about PROTACs, which are special drugs that can help break down unwanted proteins in the body.
Methodology
Data was collected from original papers in the PubMed database, focusing on PROTACs, their warheads, linkers, and E3 ligands, with pharmacokinetic parameters added in this update.
Digital Object Identifier (DOI)
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