Cardiac Function in Mice Lacking Creatine
Author Information
Author(s): Schneider Jürgen E, Stork Lee-Anne, Bell Jordana T, Hove Michiel ten, Isbrandt Dirk, Clarke Kieran, Watkins Hugh, Lygate Craig A, Neubauer Stefan
Primary Institution: University of Oxford
Hypothesis
Lack of creatine would be detrimental for resting cardiac performance during ageing.
Conclusion
GAMT knockout mice maintain normal cardiac structure and function at rest, even during ageing.
Supporting Evidence
- GAMT knockout mice showed no significant differences in cardiac function compared to wild type mice.
- The study utilized a longitudinal design to assess changes over time in the same animals.
- Cine-MRI provided accurate non-invasive measurements of cardiac parameters.
Takeaway
This study looked at mice that can't make creatine to see if their hearts would get worse as they got older, but they stayed healthy.
Methodology
High-resolution cine-MRI was used to measure cardiac structure and function at four time points over one year.
Potential Biases
Deaths during anesthesia may have introduced bias, but were not statistically significant.
Limitations
The study did not make acute measurements of cardiac functional reserve due to the non-invasive protocol.
Participant Demographics
Male and female GAMT knockout and wild type mice.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website