Glycolysis-Related Proteins in Urine Increase After Running
Author Information
Author(s): Zhao Tian, Liu Tianci, Li Tao, Chen Shengcun, Wang Lupeng, Zhang Man
Primary Institution: Beijing Key Laboratory of Urinary Cellular Molecular Diagnostics, Beijing, China
Hypothesis
The study aims to explore the changes in the expression of glucose metabolism-related proteins in urine after running.
Conclusion
The expression of glycolysis-related proteins PKM, TPI1, ENO1, and LDHB in urine was significantly increased after running, which may be applied to the monitoring of running training.
Supporting Evidence
- A total of 140 proteins were identified using LC-MS/MS in DDA mode.
- 49 urine proteins showed increased expression after running.
- PKM, TPI1, ENO1, and LDHB proteins in urine had good monitoring values for running training.
Takeaway
After running, certain proteins in urine that help break down sugar for energy go up, which could help track how well someone is training.
Methodology
Urine samples were collected before and after running, and urine proteomics information was collected using LC-MS/MS.
Limitations
The study is preliminary and needs validation in more forms of exercise and with more subjects.
Participant Demographics
20 male subjects, average age 25.80 years, height 1.73 m, weight 71.48 kg.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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