Maternal Risk Factors for Abnormal Placental Growth
Author Information
Author(s): Kesha Baptiste-Roberts, Carolyn M. Salafia, Wanda K. Nicholson, Anne Duggan, Nae-Yuh Wang, Frederick L. Brancati
Primary Institution: Johns Hopkins Bloomberg School of Public Health
Hypothesis
Lower socioeconomic status would be associated with increased likelihood of placental growth restriction.
Conclusion
Maternal risk factors are either associated with placental growth restriction or placental hypertrophy, suggesting different underlying biological mechanisms.
Supporting Evidence
- Black race was linked to higher chances of placental growth restriction.
- Hypertensive disease increased the likelihood of growth restriction for placental weight.
- Anemia was associated with lower chances of growth restriction for placental weight.
Takeaway
This study looked at how different factors in mothers, like their race and health conditions, can affect the growth of the placenta during pregnancy.
Methodology
Analysis of mother-placenta pairs using multinomial logistic regression to identify predictors of placental growth restriction and hypertrophy.
Potential Biases
Participants excluded from the analysis differed significantly from those included, which may introduce bias.
Limitations
The study used historical data from the 1950s, which may not reflect current practices and included biases due to participant exclusion.
Participant Demographics
Mean age of mothers was 24.5 years; almost half were Black, and many had low income and education levels.
Statistical Information
P-Value
0.0045
Confidence Interval
(1.54, 2.55)
Statistical Significance
p<0.0045
Digital Object Identifier (DOI)
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