Altered Expression of IGF-axis in Hepatoblastomas
Author Information
Author(s): Gray S G, Eriksson T, Ekström C, Holm S, Schweinitz D von, Kogner P, Sandstedt B, Pietsch T, Ekstöm T J
Primary Institution: Karolinska Institute
Hypothesis
The expression of insulin-like growth factor (IGF) members is altered in hepatoblastomas compared to normal liver.
Conclusion
The study found that the expression of IGF-axis members is significantly different between hepatoblastomas and normal liver tissue.
Supporting Evidence
- The expression of IGF-axis members is altered between tumor and normal liver.
- Previous reports have shown that IGF2 expression is altered in hepatoblastoma.
Takeaway
This study looked at how certain growth factors are different in liver tumors compared to normal liver, which might help us understand how these tumors develop.
Methodology
RNAase protection analysis was used to examine gene expression of various IGF members in hepatoblastomas and corresponding normal liver.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website