Vitamin C and Flavonoids for Periodontal Health
Author Information
Author(s): de Jong Thijs M. H., Stamatelou Eleni, Rosema Nanning A. M., Jansen Ineke D. C., Brandt Bernd W., Angelakis Athanasios, Loos Bruno G., van der Velden Ubele, Danser Monique M.
Primary Institution: Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam
Hypothesis
Can vitamin C supplementation, with or without flavonoids, improve periodontal conditions in untreated periodontitis patients?
Conclusion
Higher plasma vitamin C levels were associated with lower gingival inflammation, but supplementation did not show additional benefits on periodontal conditions.
Supporting Evidence
- Vitamin C levels were correlated with reduced gingival inflammation.
- Clustering analysis showed no differences based on supplementation type.
- Microbiological data had limited effects on outcomes.
Takeaway
This study looked at whether taking vitamin C helps people with gum disease. It found that while vitamin C levels were linked to less gum inflammation, taking the vitamin didn't make a big difference in treatment outcomes.
Methodology
A case series from a randomized controlled trial with a 2-month observation of untreated periodontitis followed by a 3-month period after non-surgical periodontal treatment.
Potential Biases
The study was single-blind, which may introduce bias as patients knew their supplement type.
Limitations
The study was limited by a small sample size of 13 patients due to premature termination from COVID-19.
Participant Demographics
4 females and 9 males, aged 29 to 65 years, with varying smoking habits and BMI.
Statistical Information
P-Value
0.013
Statistical Significance
p=0.013
Digital Object Identifier (DOI)
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