Suppression of local invasion of ameloblastoma by inhibition of matrix metalloproteinase-2 in vitro
2008
Inhibiting MMP-2 Reduces Ameloblastoma Invasiveness
publication
Evidence: moderate
Author Information
Author(s): Wang Anxun, Zhang Bin, Huang Hongzhang, Zhang Leitao, Zeng Donglin, Tao Qian, Wang Jianguang, Pan Chaobin
Primary Institution: Sun Yat-sen University
Hypothesis
Inhibition of MMP-2 activity is involved in the invasiveness of ameloblastomas.
Conclusion
Inhibition of MMP-2 activity suppresses the local invasiveness of ameloblastoma cells.
Supporting Evidence
- MMP-2 mRNA and protein levels were significantly inhibited by RNA interference.
- Both MMP-2 siRNA and TIMP-2 overexpression inhibited MMP-2 activity.
- Inhibition of MMP-2 activity resulted in reduced invasiveness of ameloblastoma cells.
Takeaway
This study found that blocking a specific protein called MMP-2 can help stop a type of tumor in the jaw from spreading too much.
Methodology
Plasmids containing MMP-2 siRNA or TIMP-2 cDNA were transfected into ameloblastoma cells, and various assays were performed to assess MMP-2 activity and invasiveness.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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