Impact of Haemoadsorption Therapy on Mortality in Severe Septic Shock
Author Information
Author(s): Danny Epstein, Karawan Badarni, Yaron Bar-Lavie
Primary Institution: Rambam Health Care Campus
Hypothesis
Does combining haemoadsorption therapy with continuous renal replacement therapy reduce mortality in patients with severe septic shock and acute kidney injury?
Conclusion
Haemoadsorption therapy combined with CRRT is associated with improved lactate clearance, reduced vasopressor requirements, and lower ICU and 30-day mortality.
Supporting Evidence
- Patients receiving haemoadsorption therapy had a significantly lower ICU mortality rate of 34.0% compared to 65.5% in the CRRT alone group.
- 30-day mortality was also significantly lower in the haemoadsorption group at 34.0% versus 62.1% in the control group.
- The haemoadsorption group showed significant reductions in blood lactate levels after 24 hours.
Takeaway
This study found that using a special treatment called haemoadsorption along with kidney support can help sick patients with severe infections live longer and feel better.
Methodology
A single-centre retrospective cohort study comparing patients receiving haemoadsorption therapy with CRRT to those receiving CRRT alone.
Potential Biases
Selection bias due to the decision-making process for treatment allocation being at the discretion of the attending physician.
Limitations
Single-centre study with a limited sample size and potential selection bias due to physician discretion in treatment allocation.
Participant Demographics
Most participants were male, with a median age of 66 years.
Statistical Information
P-Value
p = 0.008 for ICU mortality, p = 0.02 for 30-day mortality, p = 0.002 for 60-day mortality.
Confidence Interval
95% CI 0.05, 0.50 for ICU mortality; 95% CI 0.04, 0.48 for 30-day mortality.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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